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Obese Patients Obese patients should be dosed at the recommended adult dose using Ideal Body Weight Available as acyclovir and acyclovir sodium; dosage expressed in terms of acyclovir. Reconstitution of the 500 mg or 1,000 mg vials with 10 mL or 20 mL, respectively, of Sterile Water for Injection, USP results in a solution containing 50 mg/mL of acyclovir of acyclovir elimination, accounting for 62 to 91% of the dose administered. INTRAMUSCULAR OR SUBCUTANEOUS INJECTION MUST BE AVOIDED (see WARNINGS). Pediatric Patients Mucocutaneous, Ocular, and Systemic Herpes Simplex Virus (HSV) Infections Treatment of Mucocutaneous HSV Infections Oral† Immunocompromised children: 1 g daily given in 3–5 divided doses for 7–14 days. It is usually given over 1 hour every 8 hours. Initial treatment: 200 mg PO q4hr while awake (5 times daily) for 10 days or 400 mg PO q8hr for 7-10 days. 200 mg orally every 4 hours 5 times a day for 10 days (manufacturer dosing) 400 mg orally 3 times a day for 5 to 10 days (CDC recommendation) Severe Disease or Complications Requiring Hospitalization: 5 mg/kg IV every 8 hours for 5 days (manufacturer dosing). Consult DOSAGE AND ADMINISTRATION for recommended adjustments in dosing based upon creatinine clearance. [34408] Infants 1 to 2 months† 20 mg/kg/dose IV every 8 hours for 21 days A maximum dose equivalent to 20 mg/kg every 8 hours should not be exceeded for any patient. The peak and trough plasma levels during the 47 hours preceding hemodialysis were 8. 5 mg/kg to 6 adult patients with severe renal failure. Acyclovir was administered at a dose of 2. The length of treatment depends on your general health, the type of infection you have, your age, and how well you respond to the medication. Chronic suppression for recurrence: 400 mg PO q12hr for up to 12 months. Intermittent treatment for recurrence: 200 mg PO q4hr while awake (5 times daily) for 5 days; initiate at earliest sign or symptom of recurrence. 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days. Acyclovir injection comes as a solution to be injected intravenously (into a vein). Consult DOSAGE AND ADMINISTRATION section for recommended adjustments in dosing based upon creatinine clearance. The half-life and total body clearance of acyclovir in pediatric patients over 1 year of age is similar to those in adults with normal renal function. This provides a solution containing 25 mg Acyclovir per ml Genital Herpes. Therapy should be HOW SUPPLIED NDC - Acyclovir for Injection, USP - Packaging - 68382-125-10 - 500 mg/vial - 10 vials packed in a carton - 68382-126-10 - 1,000 mg/vial - 10 vials packed in a carton - Vial PACKAGE LABEL - PRINCIPAL DISPLAY PANEL. 61 mcg/mL) Each 500 mg vial contains 500 mg of acyclovir and 49 mg of sodium, and each 1,000 mg vial contains 1,000 mg acyclovir and 98 mg of sodium. Each 250 mg vial of Acyclovir IV Injection should be reconstituted by the addition of 10 ml of either Water for Injection or Sodium Chloride Intravenous Infusion (0. [34213] In persons living with HIV, treat for 21 days. Acyclovir for Injection, USP was administered at a dose of 2. [34361] The FDA-approved dose is 20 mg/kg/dose IV every 8 hours for 10 days. Consult DOSAGE AND ADMINISTRATION section for recommended adjustments in dosing based. This medicine must be given slowly, and the infusion can take at least 1 hour to complete Each 250 mg vial of Acyclovir IV Injection should be reconstituted by the addition of 10 ml of either Water for Injection or Sodium Chloride Intravenous Infusion (0. Dosage Herpes Simplex Infections: Mucosal and Cutaneous Herpes Simplex (HSV-1 and HSV-2) Infections in Immunocompromised Patients Adults and Adolescents (12 buy floxin without a prescription years of age and older) 5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.. Children aged between 3 months and 12 years:. NDC 63323-325-09 302520 - ACYCLOVIR SODIUM - INJECTION - 1,000 mg per 20 mL* (50 mg per mL) For IV Infusion Only - MUST BE DILUTED PRIOR TO USE - Rx only - 20 mL Single Dose PACKAGE LABEL - PRINCIPAL DISPLAY - Acyclovir 20 mL Single Dose Vial Tray Label. Thus, one 100 ml infusion bag may be used for any dose between 250 mg and 500 mg acyclovir (10 and 20 ml of reconstituted solution) but a second bag must be used for doses between 500 and 1 000 mg 10 to 15 mg/kg/dose IV every 8 hours for 14 to 21 days. Acyclovir is poorly absorbed from the GI tract, with an oral bioavailability of 10% to 20%. Varicella-Zoster Infections Zoster in immunocompromised patients: 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days. [34408] Use ideal body weight when dosing persons with obesity. INDICATIONS AND CLINICAL USE Acyclovir Sodium Injection is indicated for the treatment of initial and recurrent. Acyclovir is given as an infusion into a vein, usually once every 8 hours. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. As the administered dose increases, the bioavailability decreases, resulting in less than dose proportional increase in acyclovir concentrations (e.